System and method for single or multiple bead distribution with an adjustable capillary
AssigneeGlaxo-Wellcome, Inc., A North Carolina corporation
InventorsSvetlana Velkovska, Kerwin Ng, Haim Kedar
Life of this patent
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Abstract
A system for processing a plurality of solid supports comprises a tubular member having a proximal end, a distal end, and a lumen terminating at the distal end. A stop is positioned within the lumen at a location spaced about the distal end and is sized to permit fluids to pass through the lumen while preventing the passage of solid supports. A fluid transfer device is configured to transfer fluids through the lumen such that when a fluid containing one or more solid supports is aspirated into the lumen, a solid support may be drawn into the lumen to lodge against the stop.
Claims21
A system for processing a plurality of solid supports, the system comprising:
- a tubular member having a proximal end, a distal end, and a lumen terminating at the distal end;
- a stop positioned within the lumen at a location spaced above the distal end, wherein the stop is sized to permit fluids to pass through the lumen while preventing passage of solid supports;
- and
- a fluid transfer device that is configured to transfer fluids through the lumen such that when a fluid containing one or more solid supports is aspirated into the lumen, a solid support may be drawn into the lumen to lodge against the stop.
A device for processing solid supports that are held within a fluid, the device comprising:
- a tubular member having a proximal end, a distal end, and a lumen terminating at the distal end, wherein the lumen has a diameter in the range from about 190 μm to about 210 μm;
- a wire positioned within the lumen at a location spaced above the distal end, wherein the wire has an outer diameter in the range from about 125 μm to about 150 μm to permit fluids to pass through the lumen while preventing passage of solid supports when fluids are aspirated into the lumen from the distal end.
A method for processing solid supports having at least one chemical synthesized thereon, the method comprising:
- providing a tubular member having a proximal end, a distal end, and a lumen terminating at the distal end, and a stop that is positioned within the lumen at a location spaced above the distal end;
- placing the distal end of the tubular member into a fluid having a plurality of solid supports;
- and
- aspirating at least some of the fluid into the lumen and past the stop to draw at least one of the solid supports into the lumen until lodging against the stop.
Dependencies are inferred from the claim text.