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US 2003/0166277 A1Published application
Targeted vaccine delivery systems
AssigneeUniversity of Rochester
InventorsMaurice Zauderer, Ernest S. Smith
Life of this patent
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Abstract
The present invention is directed to a novel targeted vaccine delivery system, comprising one or more MHC-peptide complexes linked to an antibody which is specific for a cell surface marker. The complexes of the invention are useful for treating and/or preventing cancer, infectious diseases, autoimmune diseases, and/or allergies.
Claims119
A compound comprising:
- (a) one or more MHC-peptide complexes;
- and
- (b) an antibody or a fragment thereof specific for a cell surface marker;
- wherein said MHC-peptide complexes comprise an MHC class I α chain or fragment thereof, a β2-microglobulin molecule or fragment thereof, and an antigenic peptide bound in the MHC groove;
- and
- wherein said MHC-peptide complexes are linked to the carboxyl terminus of said antibody or fragment thereof.
3 more elements
A compound comprising:
- (a) one or more MHC-peptide complexes;
- and
- (b) an antibody or a fragment thereof specific for a cell surface marker;
- wherein said MHC-peptide complexes comprise an MHC class I α chain or fragment thereof, a β2-microglobulin molecule or fragment thereof, and an antigenic peptide bound in the MHC groove;
- and
- wherein said MHC class I α chain or fragment thereof of said MHC-peptide complexes are linked to the carboxyl terminus of said antibody or fragment thereof.
3 more elements
A compound comprising:
- (a) one or more MHC-peptide complexes;
- and
- (b) an antibody or fragment thereof specific for a cell surface marker;
- wherein said MHC-peptide complexes comprise an MHC class II α chain or fragment thereof, an MHC class II chain or fragment thereof, and an antigenic peptide bound in the MHC groove;
- and
- wherein at least one chain or fragment thereof of said MHC-peptide complexes are linked to the carboxyl terminus of said antibody or fragment thereof.
3 more elements
A compound comprising:
- (a) two or more MHC-peptide complexes;
- (b) a multivalent compound;
- and
- (c) an antibody or a fragment thereof specific for a cell surface marker;
- wherein said MHC-peptide complexes comprise either (i) an MHC class I α chain or fragment thereof and β2-microglobulin or fragment thereof;
- or (ii) an MHC class II α chain or fragment thereof and an MHC class II β chain or fragment thereof;
- and an antigenic peptide bound in the MHC groove;
- wherein at least one chain or fragment thereof of said MHC-peptide complexes are linked to said multivalent compound;
- and wherein said multivalent compound is linked to said antibody.
6 more elements
A polynucleotide encoding a compound comprising:
- (a) one or more MHC molecules;
- and
- (b) an antibody or fragment thereof specific for a cell surface marker;
- wherein said MHC molecules comprise an MHC class I α chain or fragment thereof and a β2-microglobulin molecule or fragment thereof;
- and wherein said MHC molecules are linked to the carboxyl terminus of said antibody or fragment thereof.
2 more elements
A polynucleotide encoding a compound comprising:
- (a) one or more MHC molecules;
- and
- (b) an antibody or fragment thereof specific for a cell surface marker;
- wherein said MHC molecules comprise an MHC class I α chain or fragment thereof and a β2-microglobulin molecule or fragment thereof;
- and wherein said a chain of said MHC molecules are linked to the carboxyl terminus of said antibody or fragment thereof.
2 more elements
A polynucleotide encoding a compound comprising:
- (a) one or more MHC molecules;
- and
- (b) an antibody or fragment thereof specific for a cell surface marker;
- wherein said MHC molecules comprise an MHC class II α chain or fragment thereof and an MHC class II β or fragment thereof;
- and wherein at least one chain or fragment thereof of said MHC molecules are linked to the carboxyl terminus of said antibody or fragment thereof.
2 more elements
A method of immunizing an animal, comprising administering to said animal a compound comprising:
- (a) one or more MHC-peptide complexes;
- and
- (b) an antibody or a fragment thereof specific for a cell surface marker;
- wherein said MHC-peptide complexes comprise an MHC class I α chain or fragment thereof, a β2-microglobulin molecule or fragment thereof, and an antigenic peptide bound in the MHC groove;
- and
- wherein said MHC-peptide complexes are linked to the carboxyl terminus of said antibody or fragment thereof.
3 more elements
A method of immunizing an animal, comprising administering to said animal a compound comprising:
- (a) one or more MHC-peptide complexes;
- and
- (b) an antibody or a fragment thereof specific for a cell surface marker;
- wherein said MHC-peptide complexes comprise an MHC class I α chain or fragment thereof, a β2-microglobulin molecule or fragment thereof, and an antigenic peptide bound in the MHC groove;
- and
- wherein said MHC class I α chain or fragment thereof of said MHC-peptide complexes are linked to the carboxyl terminus of said antibody or fragment thereof.
3 more elements
A method of immunizing an animal, comprising administering to said animal a compound comprising:
- (a) one or more MHC-peptide complexes;
- and
- (b) an antibody or fragment thereof specific for a cell surface marker;
- wherein said MHC-peptide complexes comprise an MHC class II α chain or fragment thereof, an MHC class II β chain or fragment thereof, and an antigenic peptide bound in the MHC groove;
- and
- wherein at least one chain or fragment thereof of said MHC-peptide complexes are linked to the carboxyl terminus of said antibody or fragment thereof.
3 more elements
A method of immunizing an animal, comprising administering to said animal a compound comprising:
- (a) two or more MHC-peptide complexes;
- (b) a multivalent compound;
- and
- (c) an antibody or a fragment thereof specific for a cell surface marker;
- wherein said MHC-peptide complexes comprise either (i) an MHC class I α chain or fragment thereof and β2-microglobulin or fragment thereof, or (ii) an MHC class II α chain or fragment thereof and an MHC class II β chain or fragment thereof;
- and an antigenic peptide bound in the MHC groove;
- wherein at least one chain or fragment thereof of said MHC-peptide complexes are linked to said multivalent compound;
- and wherein said multivalent compound is linked to said antibody.
5 more elements
The method of claim 1101, wherein said antigenic peptide is derived from an infectious agent or from infected cells.
Dependencies are inferred from the claim text.