Compositions and methods for reversibly inducing continual growth in normal cells
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsE. Premkumar Reddy, Sushil G. Rane, Richard V. Mettus
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Abstract
A mutant modified cyclin dependent kinase protein, or biologically active fragment, derivative, homolog or analog thereof is provided, which reversibly induces continual growth in cultured cells when administered to the cells exogenously in culture. Methods of reversibly inducing continual growth in cultured cells, and methods of screening cancer-causing agents with the continual growth-induced cells, are also provided.
Claims39
A composition for inducing a reversible state of continual growth in cultured cells, comprising at least one compound comprising a cdk4, cdk2 or cdk6 protein having an activating mutation, or biologically active fragment, derivative, homolog or analog of the cdk4, cdk2, cdk6 protein, wherein the compound further includes one or more modifications which allow the compound to enter the cells when administered to the cells in culture.
Dependencies are inferred from the claim text.