Mammalian transforming growth factor beta-10
OwnerJames L. Hollowayinventor
Life of this patent
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Abstract
Novel mammalian Ztgfβ-10 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies
Claims10
An isolated polynucleotide which encodes a polypeptide, said polypeptide being comprised of an amino acid sequence, said amino acid sequence being at least 90% identical to one or more of the amino acid sequences selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12 and SEQ ID NO:
- 13.
An expression vector comprised of a transcription promoter;
- a polynucleotide encoding a polypeptide, said polypeptide being comprised of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12 and SEQ ID NO:
- 13, wherein the promoter and the polynucleotide encoding the polypeptide are operably linked.
A cell transfected or transformed with an expression vector, said expression vector being comprised of a transcription promoter;
- a polynucleotide encoding a polypeptide, said polypeptide being comprised of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12 and SEQ ID NO:
- 13, wherein the promoter and the polynucleotide encoding the polypeptide are operably linked.
An isolated polypeptide comprised of an amino acid sequence, said amino acid sequence being at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12 and SEQ ID NO:
- 13.
An antibody which specifically binds to a polypeptide comprised of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12 and SEQ ID NO:
- 13.
A method for treating cytokine-induced inflammation comprising administering an antagonist to a polypeptide, said polypeptide being comprised of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
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A method for inhibiting viral proliferation comprising a polypeptide comprised of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.