Use of Lactobacillus salivarius
AssigneeEnterprise Ireland
InventorsJohn Kevin Collins, Gerald Christopher O'Sullivan, Liam O'Mahony, Fergus Shanahan
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Abstract
Lactobacillus salivarius is useful in the prophylaxis or treatment of undesirable inflammatory activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer. The Lactobacillus salivarius is of human origin isolated from resected and washed human gastrointestinal tract. One such strain is UCC 118 described in WO-A-9835014.
Claims50
Use of a strain of Lactobacillus salivarius in the preparation of a medicament for the prophylaxis and/or treatment of undesirable inflammatory activity.
Use as claimed in claimed 9 wherein the diarrhoel disease is associated by Clostridium difficile.
Use of a strain of Lactobacillus salivarius in the preparation of a medicament for the prophylaxis of cancer.
Use as claimed in any preceding claim wherein the strain or formulation is for administration to animals.
Use as claimed in any preceding claim wherein the Lactobacillus salivarius effects changes in an immunological marker when introduced into a system comprising cells which interact with the immune system and cells of the immune system.
Use as claimed in any preceding claim wherein the Lactobacillus salivarius strain is Lactobacillus salivarius subspecies salivarius.
Use as claimed in any preceding claim wherein the Lactobacillus salivarius is of human origin.
Use as claimed in any preceding claim wherein the Lactobacillus salivarius is isolated from resected and washed human gastrointestinal tract.
Use as claimed in any preceding claim wherein the Lactobacillus salivarius inhibits a broad range of Gram positive and Gram negative micro-organisms.
Use as claimed in any preceding claim wherein Lactobacillus salivarius secretes a product having anti-microbial activity into a cell-free supernatant, said activity being produced only by growing cells and being destroyed by proteinase K and pronase E.
Use as claimed in any preceding claim wherein the Lactobacillus salivarius strain is strain UCC 118 or a mutant or variant thereof.
Use as claimed in any preceding claim wherein the Lactobacillus salivarius is a genetically modified mutant.
Use as claimed in any preceding claim wherein the Lactobacillus salivarius is a naturally occurring variant of Lactobacillus salivarius.
Use as claimed in any preceding claim wherein the Lactobacillus salivarius is in the form of viable cells.
Use as claimed in any preceding claims wherein the Lactobacillus salivarius is in the form of non-viable cells.
Dependencies are inferred from the claim text.