Paramyxovirus-derived RNP
OwnerKaio Kitazato, Tsugumine Shu +8inventors
InventorsKaio Kitazato, Tsugumine Shu, Hidekazu Kuma, Yasuji Ueda, Makoto Asakawa, Mamoru Hasegawa, Akihiro Iida, Takahiro Hirata, Makoto Inoue, Yumiko Tokusumi
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Abstract
A functional RNP containing negative-strand single-stranded RNA derived from Sendai virus, which has been modified so as not to express at least one envelope protein, has been successfully prepared. An RNP comprising a foreign gene is prepared and inserted into a cell with the use of a cationic liposome, thereby successfully expressing the foreign gene.
Claims7
A complex comprising (a) a negative-strand single-stranded RNA derived from a paramyxovirus, wherein said RNA is modified so as not express at least one of the envelope proteins of paramyxoviruses, and (b) proteins encoded by and binding to said negative-strand single-stranded RNA.
Dependencies are inferred from the claim text.