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US 2003/0166245 A1Published application
Wasp family protein fragments, and use thereof
AssigneesCentre National De La Recherche Scientifique, Institu Curie
InventorsVincent Noireaux, Jacques Prost, Cecile Sykes, Evelyne Friedrich, Roy M Golsteyn, Daniel Louvard
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Abstract
The invention concerns peptide fragments of the WASP family proteins, or peptides derived from said fragments, and their uses in particular for preparing reagents for use in implementing a method for detecting or screening molecules with inhibiting or stimulating effect on the formation of the actin cytoskeleton, hence an inhibiting or stimulating effect on cellular motility.
Claims20
Use:
- of peptide fragments of WASP family proteins in eukaryotic cells, in particular in cells of humans or other mammals, or cells of insects or of micro-organisms such as yeasts, said peptide fragments having the property of WASP family proteins to polymerise actin, inducing cellular motility,
- or peptide sequences derived from the above-mentioned peptide fragments of WASP family proteins, in particular by substitution of one or more amino acids of these fragments, said derived sequences having the above-mentioned property of WASP family proteins and said fragments thereof,
- for the preparation of reagents which can be used within the framework of implementation of a process for the detection or screening of molecules having an inhibiting or stimulating effect on the formation of the actin cytoskeleton, and hence an inhibiting or stimulating effect on cellular motility.
Dependencies are inferred from the claim text.