US 2003/0166244 A1 · 57316 and 33338, human ubiquitin carboxyl terminal hydrolases and uses therefor

Abstract

The invention provides isolated nucleic acids molecules, designated 57316 or 33338 nucleic acid molecules, which encode ubiquitin carboxyl terminal hydrolase proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 57316 or 33338 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 57316 or 33338 gene has been introduced or disrupted. The invention still further provides isolated 57316 or 33338 proteins, fusion proteins, antigenic peptides and anti-57316 or 33338 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Claims29

Dependent claims

An isolated nucleic acid molecule selected from the group consisting of:

a. a nucleic acid molecule comprising a nucleotide sequence which is at least 80% identical to the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:6 or SEQ ID NO:3 or SEQ ID NO:9;
b. a nucleic acid molecule comprising a fragment of at least 2000 nucleotides of the nucleotide sequence of SEQ ID NO:1 or at least 700 nucleotides of the nucleotide sequence of SEQ ID NO:3;
c. a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:8;
and
d. a nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:7, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule comprising SEQ ID NO:1 or SEQ ID NO:6 or 3, or a complement thereof, under stringent conditions.

2 more elements

Dependencies are inferred from the claim text.

57316 and 33338, human ubiquitin carboxyl terminal hydrolases and uses therefor

Life of this patent

57316 and 33338, human ubiquitin carboxyl terminal hydrolases and uses therefor

Life of this patent

Abstract

Claims29