US 2003/0166231 A1 · Novel human RNA-binding protein

Abstract

The present invention provides a human RNA binding protein (HRNABP) and polynucleotides which identify and encode HRNABP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HRNABP and a method for producing HRNABP. The invention also provides for antagonists or antibodies specifically binding HRNABP, and their use, in the prevention and treatment of diseases associated with expression of HRNABP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HRNABP for the treatment of diseases associated with the expression of HRNABP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HRNABP.

Claims57

Dependent claims

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

a) a polypeptide comprising an amino acid sequence of SEQ ID NO:1,
b) a naturally occurring polypeptide comprising an amino acid sequence at least 90% identical to an amino acid sequence of SEQ ID NO:1,
c) a biologically active fragment of a polypeptide having an amino acid sequence of SEQ ID NO:1, and
d) an immunogenic fragment of a polypeptide having an amino acid sequence of SEQ ID NO:
1.

2 more elements

Dependencies are inferred from the claim text.

Novel human RNA-binding protein

Life of this patent

Novel human RNA-binding protein

Life of this patent

Abstract

Claims57