US 2003/0166229 A1 · Human POSH-like protein 1

Abstract

The invention provides isolated nucleic acids that encode human POSHL1, and fragments thereof, vectors for propagating and expressing human POSHL1 nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel human POSHL1 isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human POSHL1 nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human POSHL1 gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the human POSHL1 nucleic acids, proteins, and antibodies of the present invention.

Claims47

Dependent claims

An isolated nucleic acid that encodes a POSH-like onco-protein that interacts with both small GTPases and the downstream effectors in the signal transduction pathway, comprising:

(a) a nucleotide sequence selected from the group consisting of:
(i) SEQ ID NO:
1;
(ii) the complement of the sequences set forth in (i);
(iii) the nucleotide sequence of SEQ ID NO:
2;
(iv) a degenerate variant of the sequences set forth in (iii);
and
(v) the complement of the sequences set forth in (iii) and (iv);
or
(b) a nucleotide sequence selected from the group consisting of:
(i) a nucleotide sequence that encodes a polypeptide having the sequence of SEQ ID NO:
3;
(ii) a nucleotide sequence that encodes a polypeptide having the sequence of of SEQ ID NO:
3, with conservative amino acid substitutions;
and
(iii) the complement of the sequences set forth in (i) and (ii),
wherein said isolated nucleic acid comprising a nucleotide sequence selected from group (b) is no more than about 100 kb in length.

15 more elements

Dependencies are inferred from the claim text.

Human POSH-like protein 1

Life of this patent

Human POSH-like protein 1

Life of this patent

Abstract

Claims47