IL-17 like molecules and uses thereof
OwnerShuqiang Jing, Michael B. Bassinventors
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Abstract
Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the diagnosis, treatment, or prevention of diseases with IL-17 like polypeptides or antagonists thereof.
Claims56
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
- (a) the nucleotide sequence as set forth in SEQ ID NO:
- 1;
- (b) a nucleotide sequence encoding the polypeptide as set forth in SEQ ID NO:
- 2;
- (c) a nucleotide sequence which hybridizes under moderately or highly stringent conditions to the complement of (a) or (b);
- and
- (d) a nucleotide sequence complementary to any of (a)-(c):
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence encoding a polypeptide that is at least about 70, 75, 80, 85, 90, 95, 96, 97, 98, or 99 percent identical to the polypeptide as set forth in SEQ ID NO:
- 2, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (b) a nucleotide sequence encoding an allelic variant or splice variant of the nucleotide sequence as set forth in SEQ ID NO:
- 1;
- (c) a nucleotlde sequence of SEQ ID NO:
- 1;
- (a);
- or (b) encoding a polypeptide fragment of at least about 25 amino acid residues, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (d) a nucleotide sequence of SEQ ID NO:
- 1, or (a)-(c) comprising a fragment of at least about 16 nucleotides;
- (e) a nucleotide sequence which hybridizes under moderately or highly stringent conditions to the complement of any of (a)-(d);
- and
- (f) a nucleotide sequence complementary to any of (a)-(c).
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence encoding a polypeptide as set forth in SEQ ID NO:
- 2 with at least one conservative amino acid substitution, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (b) a nucleotide sequence encoding a polypeptide as set forth in SEQ ID NO:
- 2 with at least one amino acid insertion, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (c) a nucleotide sequence encoding a polypeptide as set forth in SEQ ID NO:
- 2 with at least one amino acid deletion, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (d) a nucleotide sequence encoding a polypeptide as set forth in SEQ ID NO:
- 2 which has a C- and/or N-terminal truncation, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (e) a nucleotide sequence encoding a polypeptide as set forth in SEQ ID NO:
- 2 with at least one modification selected from the group consisting of amino acid substitutions, amino acid insertions, amino acid deletions, C-terminal truncation, and N-terminal truncation, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (f) a nucleotide sequence of any of (a)-(e) comprising a fragment of at least about 16 nucleotides;
- (g) a nucleotide sequence which hybridizes under moderately or highly stringent conditions to the complement of any of (a)-(f);
- and
- (h) a nucleotide sequence complementary to any of (a)-(e).
An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 2.
An isolated polypeptide comprising the amino acid sequence selected from the group consisting of:
- (a) the mature amino acid sequence as set forth in SEQ ID NO:
- 3, comprising a mature amino terminus at residue 45, optionally further comprising an amino-terminal methionine;
- (b) an amino acid sequence for an ortholog of SEQ ID NO:
- 2;
- (c) an amino acid sequence that is at least about 70, 80, 85, 90, 95, 96, 97, 98, or 99 percent identical to the amino acid sequence of SEQ ID NO:
- 2, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (d) a fragment of the amino acid sequence set forth in SEQ ID NO:
- 2 comprising at least about 25 amino acid residues, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (e) an amino acid sequence for an allelic variant or splice variant of either the amino acid sequence as set forth in SEQ ID NO:
- 2, or at least one of (a)-(c) wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2.
An isolated polypeptide comprising the amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence as set forth in SEQ ID NO:
- 2 with at least one conservative amino acid substitution, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (b) the amino acid sequence as set forth in SEQ ID NO:
- 2 with at least one amino acid insertion, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (c) the amino acid sequence as set forth in SEQ ID NO:
- 2 with at least one amino acid deletion, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- (d) the amino acid sequence as set forth in SEQ ID NO:
- 2 which has a C- and/or N-terminal truncation, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2;
- and
- (e) the amino acid sequence as set forth in SEQ ID NO:
- 2, with at least one modification selected from the group consisting of amino acid substitutions, amino acid insertions, amino acid deletions, C-terminal truncation, and N-terminal truncation, wherein the polypeptide has an activity of the polypeptide as set forth in SEQ ID NO:
- 2.
An antibody produced by immunizing an animal with a peptide comprising an amino acid sequence of SEQ ID NO:
- 2.
A hybridoma that produces a monoclonal antibody that binds to a peptide comprising an amino acid sequence of SEQ ID NO:
- 2.
A selective binding agent or fragment thereof that specifically binds at least one polypeptide wherein said polypeptide comprises the amino acid sequence selected from the group consisting of:
- a) the amino acid sequence as set forth in SEQ ID NO:
- 2;
- and
- b) a fragment of the amino acid sequence set forth in at least one of SEQ ID NO:
- 2;
- or a naturally occurring variant thereof.
A selective binding agent or fragment thereof comprising at least one complementarity determining region with specificity for a polypeptide having the amino acid sequence of SEQ ID NO:
- 2.
A selective binding agent produced by immunizing an animal with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.