Gene that imparts selective proliferative activity
OwnerKeiya Ozawa, Katsuhisa Itoh +5inventors
InventorsKeiya Ozawa, Katsuhisa Itoh, Tsuneaki Sakata, Yasuji Ueda, Mamoru Hasegawa, Takeyuki Nagashima, Akihiro Kume
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Abstract
Selective amplification of cells is enabled by introducing into cells a gene encoding a fusion protein comprising (a) a ligand-binding domain, (b) a domain that associates when the ligand binds to the domain of (a), and (c) a domain that imparts proliferation activity to the cells upon the association and stimulating the cells with the ligand.
Claims20
A fusion protein comprising (a) a ligand-binding domain, (b) a domain that associates when a ligand binds to the domain of (a), and (c) a domain comprising a cytokine receptor or a part thereof that imparts proliferation activity to a cell upon the association.
A vector comprising a desired exogenous gene and a gene encoding a fusion protein comprising (a) a ligand-binding domain, (b) a domain that associates when a ligand binds to the domain of (a), and (c) a domain that imparts proliferation activity to a cell upon the association.
Dependencies are inferred from the claim text.