Zsig67: a member of the human secretin-glucagon-VIP hormone family
OwnerPaul O. Sheppard, Kimberly E. Shoemaker +2inventors
InventorsPaul O. Sheppard, Kimberly E. Shoemaker, Monica L. Tackett, Stephen R. Jaspers
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Abstract
The secretin-glucagon-vasoactive intestinal peptide (VIP) family includes polypeptidic hormones that are crucial regulators of pancreatic, biliary, and gastrointestinal physiology. By virtue of their important biological functions, these polypeptides have been developed as therapeutics and as diagnostic tools. Zsig67 is a new member of the human secretin-glucagon-VIP family.
Claims20
An isolated polypeptide comprising an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID NO:2, wherein the isolated polypeptide specifically binds with an antibody that specifically binds with a polypeptide consisting of the amino acid sequence of SEQ ID NO:2.
An isolated polypeptide selected from the group consisting of:
- (a) a polypeptide comprising the amino acid sequence of amino acid residues 29 to 45 of SEQ ID NO:2, (b) a polypeptide comprising the amino acid sequence of amino acid residues 51 to 63 of SEQ ID NO:2, (c) a polypeptide comprising the amino acid sequence of amino acid residues 52 to 101 of SEQ ID NO:2, (d) a polypeptide comprising the amino acid sequence of amino acid residues 68 to 92 of SEQ ID NO:2, (e) a polypeptide comprising the amino acid sequence of amino acid residues 70 to 101 of SEQ ID NO:2, and (f) a polypeptide comprising the amino acid sequence of amino acid residues 73 to 92 of SEQ ID NO:2.
An isolated nucleic acid molecule, wherein the nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:3, (b) a nucleic acid molecule encoding the amino acid sequence of SEQ ID NO:2, and (c) a nucleic acid molecule that remains hybridized following stringent wash conditions to a nucleic acid molecule consisting of the nucleotide sequence of nucleotides 111-422 of SEQ ID NO:1, or the complement of nucleotides 111-422 of SEQ ID NO:1.
Dependencies are inferred from the claim text.