Endogenous and non-endogenous versions of human G protein-coupled receptors
OwnerRuoping Chen, Huong T. Dang +1inventors
InventorsRuoping Chen, Huong T. Dang, Kevin P. Lowitz
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Abstract
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown (“orphan GPCR receptors”), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.
Claims80
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:2.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:1.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:4.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:3.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:6.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:5.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:8.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:7.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:10.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:9.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:
- 12.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:11.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:14.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:
- 13.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:
- 16.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:15.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:
- 18.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:17.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:20.
A plasmid comprising a vector and the cDNA of SE.ID.NO.:19.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:22.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:21.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:24.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:23.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:26.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:25.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:28.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:27.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:30.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:29.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:32.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:95.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:34.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:33.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:36.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:35.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:38.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:37.
A G protein-coupled receptor encoded by an amino acid sequence of SEQ.ID.NO.:40.
A plasmid comprising a vector and the cDNA of SEQ.ID.NO.:39.
Dependencies are inferred from the claim text.