Rotavirus VP6 subunit
OwnerAnthony H. Choi, Richard L. Wardinventors
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Abstract
The present invention relates to vaccine compositions comprising the VP6 protein from mouse (EDIM) and human (CJN) rotavirus strains. Methods of making the described immunogenic VP6 proteins and methods of using the described compositions are also disclosed.
Claims21
An isolated and purified recombinant human rotavirus VP6 polypeptide comprising an amino acid sequence having at least 98% amino acid sequence identity to SEQ. ID. NO. 4.
An immunogenic composition comprising a recombinant human rotavirus VP6 polypeptide comprising an amino acid sequence having at least 98% identity to SEQ. ID. NO. 4 and a pharmaceutical carrier.
A recombinant rotavirus fusion protein composition comprising:
- a) a recombinant human CJN rotavirus VP6 protein;
- b) a fusion protein partner in genetic association with said human CJN rotavirus VP6 protein;
- c) an adjuvant;
- and
- d) a pharmaceutical carrier;
- wherein said adjuvant is effective in stimulating a disease-reducing immunogenic response to said rotavirus fusion protein.
Dependencies are inferred from the claim text.