Minicells comprising membrane proteins
OwnerRoger A. Sabbadini, Mark W. Surber +3inventors
InventorsRoger A. Sabbadini, Mark W. Surber, Neil Berkley, Anca M. Segall, Robert Klepper
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Abstract
The invention provides compositions and methods for the production of achromosomal and anucleate cells useful for applications such as diagnositic and therapeutic uses, as well as research tools and agents for drug discovery.
Claims20
A minicell comprising a membrane protein selected from the group consisting of a eukaryotic membrane protein, an archeabacterial membrane protein and an organellar membrane protein.
A minicell comprising a membrane fusion protein, said fusion protein comprising a first polypeptide, said first polypeptide comprising at least one transmembrane domain or at least one membrane anchoring domain;
- and a second polypeptide, wherein said second polypeptide is not derived from a eubacterial protein and is neither a His tag nor a glutathione-S-transferase polypeptide.
A minicell comprising a membrane conjugate, wherein said membrane conjugate comprises a membrane protein chemically linked to a conjugated compound.
Dependencies are inferred from the claim text.