Compositions and methods for the therapy and diagnosis of colon cancer
AssigneeCorixa Corporation
InventorsGordon E. King, Madeleine Joy Meagher, Jiangchun Xu, Heather Secrist, Yuqiu Jiang
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Abstract
Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
Claims17
An isolated polynucleotide comprising a sequence selected from the group consisting of:
- (a) sequences provided in SEQ ID NOs:1-1788 and 1790-1981;
- (b) complements of the sequences provided in SEQ ID NOs:1-1788 and 1790-1981;
- (c) sequences consisting of at least 20 contiguous residues of a sequence provided in SEQ ID NOs:1-1788 and 1790-1981;
- (d) sequences that hybridize to a sequence provided in SEQ ID NOs:1-1788 and 1790-1981, under moderately stringent conditions;
- (e) sequences having at least 75% identity to a sequence of SEQ ID NOs:1-1788 and 1790-1981;
- (f) sequences having at least 90% identity to a sequence of SEQ ID NOs:1-1788 and 1790-1981;
- and
- (g) degenerate variants of a sequence provided in SEQ ID NOs:1-1788 and 1790-1981.
An oligonucleotide that hybridizes to a sequence recited in SEQ ID NOs:1-1788 and 1790-1981 under moderately stringent conditions.
Dependencies are inferred from the claim text.