7 transmembrane receptor family member blrx
AssigneesSchering Corporation, Canji, Inc.
InventorsJoseph A. Hedrick, Bernhard Homey, Alain Vicari, Monica L. Zepeda, Albert Zlotnik
Life of this patent
Estimating the term…
Abstract
Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are disclosed. Methods of using the chemokines, receptors, reagents and diagnostic kits are also provided.
Claims36
An isolated polypeptide comprising:
- a) the amino acid sequence of SEQ ID NO:
- 8;
- b) the amino acid sequence of SEQ ID NO:
- 6, or
- c) the amino acid sequence of SEQ ID NO:
- 2.
An antigenic polypeptide comprising:
- a) an immunogenic amino acid sequence exhibiting identity overall length of at least 12 amino acids to SEQ ID NO:
- 8;
- b) an immunogenic amino acid sequence exhibiting identity over a length of at least 12 amino acids to SEQ ID NO:
- 6;
- or
- c) an immunogenic amino acid sequence exhibiting identity over a length of at least 12 amino acids to SEQ ID NO:
- 2.
A nucleic acid which:
- a) hybridizes under wash conditions of 45° C. and less than 700 mM salt to SEQ ID NO:
- 1;
- b) hybridizes under wash conditions of 45° C. and less than 700 mM salt to SEQ ID NO:
- 5;
- c) hybridizes under wash conditions of 45° C. and less than 700 mM salt to SEQ ID NO:
- 7;
- d) exhibits identity over a stretch of 30 nucleotides to SEQ ID NO:
- 7;
- e) exhibits identity over at least 30 nucleotides to SEQ ID NO:
- 5;
- or
- f) exhibits identity over at least 30 nucleotides to SEQ ID NO 1.
An isolated polypeptide, comprising the amino acid sequence of SEQ ID NO:8, or a polypeptide having at least about 80% sequence homology thereto.
A method of treating a wound comprising modulating the in vivo expression of an endogenous polynucleotide in the region of the wound, wherein the polynucleotide encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:8.
Dependencies are inferred from the claim text.