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US 2003/0166049 A1Published application
Human secreted protein, Zsig47
OwnerPaul O. Sheppard, Teresa Gilbertinventors
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Abstract
Novel soluble, and membrane bound, Zsig47 polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting and modifying inflammation and the immune response.
Claims21
An isolated polypeptide comprising the amino acid sequence as shown in SEQ ID NO:
- 2 from residue 35 to residue 282.
An isolated nucleic acid molecule comprising the nucleotide sequence as shown in SEQ ID NO:
- 1 from nucleotide 144 to nucleotide 887.
A method of producing an antibody comprising the following steps in order:
- inoculating an animal with a polypeptide selected from the group consisting of:
- (a) a polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 2 from residue 35 to residue 282;
- (b) a polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 2 from residue 35 to residue 305;
- (c) a polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 2 from residue 35 to residue 334;
- and
- (d) a polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 2 from residue 1 to residue 334;
- wherein the polypeptide elicits an immune response in the animal to produce the antibody;
- and isolating the antibody from the animal.
9 more elements
Dependencies are inferred from the claim text.