TIMM8b-related protein
OwnerJennifer L. Hillmaninventor
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Abstract
The invention provides a cDNA which encodes TIMM8 b-related protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly breast cancer, ovarian cancer, and kidney cancer; and neurodegenerative disorders, particularly Mohr-Tranebjaerg syndrome, epilepsy, spasticity, and dystonia. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
Claims20
An isolated cDNA comprising a nucleic acid sequence encoding a protein having the amino acid sequence of SEQ ID NO:1, or the complement thereof.
An isolated cDNA comprising a nucleic acid sequence selected from:
- a) SEQ ID NO:2 or the complement thereof;
- b) a fragment of SEQ ID NO:2 selected from SEQ ID NOs:3-5 or the complement thereof;
- and
- c) a variant of SEQ ID NO:2 selected from SEQ ID NOs:6-11 or the complement thereof.
Dependencies are inferred from the claim text.