Compositions, test kits and methods for detecting helicobacter pylori
OwnerGeorge Sachs, Petra Volandinventors
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Abstract
Four proteins are obtained from H. pylori bacteria each of which has regions which act as antigens specific to H. pylori. The proteins are isolated, purified and designated HP1, HP2, HP3, and HP4 with respective molecular weights of 32 kd, 30 kd, 23 kd and 15 kd. An assay, a method and a kit is developed utilizing a combination of at least three of these protein to detect the presence of antibodies to H. pylori in human sera. The method of detection is quantified and suitable for monitoring the eradication of H. pylori bacteria by drug therapy of human patients infected by these bacteria.
Claims27
A composition comprising at least three proteins, wherein the proteins is selected from the group consisting of HP1, HP2, HP3 and HP4, each of said proteins comprising regions which act as antigens specific to Helicobacter pylori, HP1 having of molecular weight of 32 kd, HP2 having of molecular weight of 30 kd, HP3 having of molecular weight of 23 kd, and HP4 having of molecular weight of 15 kd, each of said proteins being derived from Helicobacter pylori bacteria.
A method of using a combination of at least 3 proteins from Helicobacter pylori for detecting the presence or absence of antibodies resulting from Helicobacter pylori infection wherein the proteins are selected from the group consisting of HP1, HP2, HP3 and HP4, each of said proteins comprising regions which act as antigens specific to Helicobacter pylori, HP1 having of molecular weight of 32 kd, HP2 having of molecular weight of 30 kd, HP3 having of molecular weight of 23 kd, and HP4 having of molecular weight of 15 kd, each of said proteins being derived from Helicobacter pylori bacteria.
Dependencies are inferred from the claim text.