Receptor polypeptides and their production and uses
AssigneeGenentech, Inc.
InventorsEdward T. Cox, Jennie P. Mather, Mary B. Sliwkowski, Teresa K. Woodruff
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Abstract
An isolated TGF-β supergene family (TSF) receptor polypeptide is provided. This polypeptide preferably is an inhibin/activin receptor polypeptide and has at least 75% sequence identity with the mature human inhibin/activin receptor sequence. Also provided is a method for purifying TGF-β supergene family members such as inhibin or activin using the polypeptide, and a method for screening for compounds with TGF-β supergene family member activity by contacting the compound with the polypeptide and detecting if binding has occurred and the compound is active.
Claims18
An isolated TSF receptor polypeptide.
An isolated inhibin/activin receptor polypeptide.
An isolated TSF receptor nucleic acid molecule.
Dependencies are inferred from the claim text.