Nucleic acid encoding a G-protein-coupled receptor, and uses thereof
OwnerHaifeng Eishingdrelo, Holly Dressler +2inventors
InventorsHaifeng Eishingdrelo, Holly Dressler, Jidong Cai, Paul Wright
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Abstract
Provided herein is a novel and useful G-protein coupled receptor that is involved in signal transduction with respect to inflammation and physiological immunological response. Also provided are methods of using the receptor to screen for molecules that may modulate the activity of the receptor. Such molecules may readily have applications in treating a plethora of inflammation and immunologically related diseases and disorders.
Claims28
An isolated nucleic acid molecule comprising the DNA sequence of FIG. 1 (SEQ ID NO:1).
A purified polypeptide comprising the amino acid sequence of FIG. 2 (SEQ ID NO:2).
A method for identifying an agonist of GAVE19 comprising:
- contacting a potential agonist with a cell expressing GAVE19 and determining whether in the presence of said potential agonist the signaling activity of GAVE19 is increased relative to the activity of GAVE19 in the absence of said potential agonist.
A method for identifying an inverse agonist of GAVE19 comprising:
- contacting a potential inverse agonist with a cell expressing GAVE19 and determining whether in the presence of said potential inverse agonist, the activity of GAVE19 is decreased relative to the activity of GAVE19 in the absence of said potential inverse agonist, and is decreased in the presence of an endogenous ligand or agonist.
A method for identifying an antagonist of GAVE19 comprising:
- contacting a potential antagonist with a cell expressing GAVE19 and determining whether in the presence of said potential antagonist the signaling activity of GAVE19 is decreased relative to the activity of GAVE19 in the presence of an endogenous ligand or agonist.
A therapeutic composition comprising an agonist, an antagonist, or an inverse agonist of GAVE19 capable of modulating GAVE19 signaling activity or transduction.
A method for treating a disease comprising administering to a patient in need of treatment a therapeutic composition comprising an agonist, an antagonist or an inverse agonist of GAVE19 capable of modulating GAVE19 signaling activity or transduction.
Dependencies are inferred from the claim text.