Glucose-1-phosphate thymidylyltransferase and method for selecting inhibitors thereof
OwnerJames Naismith, Wulf Blankenfeldtinventors
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Abstract
There is provided a method of obtaining selecting agents which inhibit the enzyme glucose-1-phosphate thymidylyltransferase (Rm1A) based upon analysis of a model of the active and regulatory site (s) of Rm1A and interaction therewith by a potential inhibitory agent. The invention is based upon the provision of information on the structure of Rm1A obtained through X-ray diffraction studies since a crystallised form of Rm1A was obtained for the first time. The purified and crystallised from of Rm1A, obtained from Psemdomononas aeruginosa is also described.
Claims18
A method of selecting agents which inhibit the enzyme glucose-1-phosphate thymidylyltransferase (RmlA), said method comprising the steps of:
- a) providing a model of the active or regulatory site(s) of RmlA;
- b) reviewing the structure of a potential inhibitory agent for at least one of these sites;
- and
- c) analysing the potential interaction of said agent in said site(s).
A purified and crystallised form of the enzyme glucose-1-phosphate thymidylyltransferase (RmlA) obtained from Pseudomonas aeruginosa.
Dependencies are inferred from the claim text.