Device and method for multiparallel synthesis and screening
OwnerSergey A. Kozmin, Ying Wanginventors
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Abstract
A device and method for a multiparallel synthesis and screening using a three-dimensional array comprising a plurality of reaction wells having a means for delivery of a fluid or solid along three directions corresponding to the x, y, and z axes of the array. The invention makes use of a plurality of removable sealing elements each of which is positioned across or spans two sides of a reaction well when in a sealing position. The reaction wells may be made of materials such as polypropylene. The sealing elements may be in the form of cylinders, tubes, rods, or tapered pins. The amount of a reaction product produced in the synthesis can be as much as 5 mg or more.
Claims24
A device for multiparallel synthesis or screening comprising
- (a) a plurality of reaction wells for receiving a fluid or solid,
- (b) a means for introducing the fluid or solid into one or more reaction wells of said plurality, and
- (c) a plurality of removable sealing elements each of which is positioned across, or spans two sides of, a reaction well when in a sealing position.
A device for multiparallel synthesis or screening comprising
- (a) a plurality of reaction wells that form a three dimensional array for receiving a fluid or solid, and
- (b) a means for introducing the fluid or solid into a plurality of inlets at two or more adjacent faces or surfaces of the three-dimensional array.
A device for multiparallel synthesis or screening comprising
- (a) a plurality of reaction wells for receiving a fluid or solid,
- (b) a means for introducing a fluid or solid into a first row of reaction wells,
- (c) a means for introducing a fluid or solid into a second row of reaction wells which is perpendicular to the first row of reaction wells, and
- (d) a means for introducing a fluid or solid into a column of reaction wells which is perpendicular to the first row and the second row of reaction wells.
A method for synthesizing or screening compounds comprising
- (a) introducing a fluid or solid into a first row of reaction wells,
- (b) introducing a fluid or solid into a second row of reaction wells that lie perpendicular to the first row of reaction wells,
- (c) introducing a fluid or solid into a column of reaction wells that lie perpendicular to each of the first row and the second row of reaction wells, and
- (d) inserting a plurality of removable sealing elements.
A method for synthesizing or screening compounds comprising
- (a) introducing a fluid or solid into a plurality of inlets at two or more adjacent faces or surfaces of a three-dimensional array that comprises a plurality of reaction wells, and
- (b) inserting a plurality of removable sealing elements.
Dependencies are inferred from the claim text.