Method for detecting a predisposition to asthma and atopy
OwnerChaker Adra, Taro Shirakawa +1inventors
InventorsChaker Adra, Taro Shirakawa, Klaus Arne Deichmann
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Abstract
We have now discovered a new method for detection of a predisposition to atopy and asthma. This method involves analyzing human chromosome 5q31 for a coding variant of human IL-13, Gln110Arg.
Claims10
A method for detecting a predisposition to asthma or atopy in an individual, the method comprising:
- analyzing a biological specimen from said individual for the presence of a Il-13 Gln110Arg variant;
- wherein the presence of said variant is indicative of an increased susceptibility to asthma or atopy.
An isolated nucleic acid molecule encoding a Gln110Arg IL-3 variant.
A non-human transgenic animal model for Gln110Arg IL-13 gene function comprising an exogenous and stably transmitted mammalian Gln110Arg IL-13 gene sequence.
A method of screening for biologically active agents that modulate Gln110Arg IL-13 function, the method comprising:
- combining a candidate biologically active agent with any one of:
- (a) Gln110Arg IL-13 polypeptide;
- (b) a cell comprising a nucleic acid encoding Gln110Arg IL-13 variant polypeptide;
- or
- (c) a non-human transgenic animal model for Gln110Arg gene function comprising an exogenous and stably transmitted mammalian Gln110Arg IL-13 gene sequence and determining the effect of said agent on Gln110Arg IL-13 variant function.
Dependencies are inferred from the claim text.