Peroxisome proliferator-activated receptor alpha and disorders of lipid metabolism

An oligonucleotide microarray having immobilized thereon a plurality of probes, wherein at least one of said probes is specific for the isolated nucleic acid molecule comprising all or a portion of at least 10 contiguous nucleotides of the PPARα nucleotide sequence, as exemplified by SEQ ID NO:

• 1, or an allelic varient thereof, wherein the isolated nucleic acid molecule comprises a polymorphic site at the first nucleotide position of codon 162 of the PPARα gene which is occupied by a guanine (G), and wherein said probe comprises the polymorphic site.

An isolated nucleic acid molecule comprising all or a portion of at least 10 contiguous nucleotides of the PPARα nucleotide sequence, as exemplified by SEQ ID NO:

• 1, or an allelic varient thereof, wherein the isolated nucleic acid molecule comprises a polymorphic site at nucleotide position 696 of the PPARα gene which is occupied by a guanine (G), and complements of said isolated nucleic acid molecule.

An oligonucleotide microarray having immobilized thereon a plurality of probes, wherein at least one of said probes is specific for an isolated nucleic acid molecule comprising all or a portion of at least 10 contiguous nucleotides of the PPARα nucleotide sequence, as exemplified by SEQ ID NO:

• 1, or an allelic varient thereof, wherein the isolated nucleic acid molecule comprises a polymorphic site at nucleotide position 696 of the PPARα gene which is occupied by a guanine (G), and wherein said probe comprises the polymorphic site.

An isolated nucleic acid molecule comprising all or a portion of at least 10 contiguous nucleotides of the PPARα nucleotide sequence, as exemplified by SEQ ID NO:

• 1, or an allelic varient thereof, wherein the isolated nucleic acid molecule comprises a polymorphic site at nucleotide position 971 of the PPARα gene which is occupied by an adenine (A), and complements of said isolated nucleic acid molecule.

A nucleic acid molecule which specifically hybridizes under conditions of high stringency to an isolated nucleic acid molecule comprising all or a portion of at least 10 contiguous nucleotides of the PPARα nucleotide sequence, as exemplified by SEQ ID NO:

• 1, or an alletic varient thereof, wherein the isolated nucleic acid molecule comprises a polymorphic site at nucleotide position 971 of the PPARα gene which is occupied by an adenine (A) and wherein said nucleic acid molecule comprises the polymorphic site.

A nucleic acid molecule which has at least 90% sequence identity with an isolated nucleic acid molecule comprising all or a portion of at least 10 contiguous nucleotides of the PPARα nucleotide sequence, as exemplified by SEQ ID NO:

• 1, or an allelic varient thereof, wherein the isolated nucleic acid molecule comprises a polymorphic site at nucleotide position 971 of the PPARα gene which is occupied by an adenine (A) and wherein said nucleic acid molecule comprises the polymorphic site.

An oligonucleotide microarray having immobilized thereon a plurality of probes, wherein at least one of said probes is specific for an isolated nucleic acid molecule comprising all or a portion of at least 10 contiguous nucleotides of the PPARA nucleotide sequence, as exemplified by SEQ ID NO:

• 1, or an allelic varient thereof, wherein the isolated nucleic acid molecule comprises a polymorphic site at nucleotide position 971 of the PPARα gene which is occupied by an adenine (A) and wherein said probe comprises the polymorphic site.

An isolated nucleic acid molecule comprising all or a portion of at least 275 contiguous nucleotides of the PPARα nucleotide sequence, as exemplified by SEQ ID NO:

• 1, or an allelic varient thereof, wherein the isolated nucleic acid molecule comprises a polymorphic site at nucleotide position 696 of the PPARα gene and a polymorphic site at nucleotide position 971 of the PPARα gene which are occupied by a guanine (G) and an adenine (A), respectively, and complements of said isolated nucleic acid molecule.

An oligonucleotide microarray having immobilized thereon a plurality of probes, wherein at least one of said probes is specific for the isolated nucleic acid molecule comprising all or a portion of at least 275 contiguous nucleotides of the PPARα nucleotide sequence, as exemplified by SEQ ID NO:

• 1, or an allelic varient thereof, wherein the isolated nucleic acid molecule comprises a polymorphic site at nucleotide position at nucleotide position 696 of the PPARα gene and a polymorphic site at nucleotide position 971 of the PPARα gene which is occupied by a guanine (G) and an adenine (A), respectively, and wherein said probe comprises the polymorphic sites.