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US 2003/0165969 A1Published application
Non-nucleotide containing enzymatic nucleic acid
AssigneeRibozyme Pharmaceuticals, Inc.
InventorsNassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alexander Karpeisky
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Abstract
Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
Claims6
A double stranded RNA molecule comprising at least one of the non-nucleotide moieties selected from the group consisting of:
- 1
- wherein, said “n” is an integer of between 1 and 10;
- X is independently oxygen, nitrogen, sulfur or substituted carbons including alkyl or alkene;
- R is independently an H, alkyl, alkenyl or alkynyl of 1-10 carbon atoms;
- and Y is independently a phosphodiester, ether or amide linkage to the nucleic acid molecule.
2 more elements
A double stranded RNA molecule comprising at least one non-nucleotide moiety, wherein said non-nucleotide moiety lacks a nucleic acid base and wherein said non-nucleotide comprises a nucleotide sugar and phosphate component.
Dependencies are inferred from the claim text.