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US 2003/0165954 A1Published application
Cancer profiles
AssigneeThird Wave Technologies, Inc.
InventorsToyomasa Katagiri, Yasuyuki Ohnishi, Yusuke Nakamura
Life of this patent
Estimating the term…
Abstract
The present invention relates to genetic profiles and markers of cancers and provides systems and methods for screening drugs that are effective for specific patients and types of cancers. In particular, the present invention provides personalized treatment customized to an individual's cancer.
Claims28
A method, comprising:
- a) providing a sample from a subject diagnosed with cancer;
- and
- b) generating a drug sensitivity profile for said sample;
- wherein said generating a drug sensitivity profile comprises detecting a level of expression of two or more drug sensitivity genes selected from the group consisting of ADAMTS2, MSH6, MAGEA6, RPS6KB1, PIK3CB, MDR3, MDR4, MDR9, OS4, KIAA1140, GCNT3, FARP1, PP1044, C11ORF15, KIAA0233, BZRP, PRPS1, HGFAC, TRPC4, LOC56889, FLJ20208, FLJ22833, PGLYRP, TNFRSF14, HLA-B, NPR3, DES, PCDH1, LLGL2, HMGCL, TSPAN, ANXA4, ABP1, ERP70, HSD17B2, FBP1, SIM1, LAF4, CRKL, TOB2, GDA, MMP7, PRSS8, CKS2, PGLYRP, KIF4A, PABPC1, FLJ21865, ETV4, EXTL3, PIK3C2A, DNMT3B, DKFZP566G1424, KIAA0026, CCNB1, GPC3, EVA1, FSTL3, MSLN, FLJ21935, DES, STK17A, KCNH2, DLK1, CPX, NRP1, PCTAIRE2BP, ELF3, AGR2, FLJ10849, ATP1B1, GPX2, SLI, AMPD1, OTC, MMP3, CPX, COX6A2, S100A4, LOC51315, MDS024, PCDH1, PGLYRP, NK4, TRAF2, ARHE, LOC51256, ITGA3, KLAA0971, KIAA1037, GABRA6, U1SNRNPBP, MYBL2, POLA2, TRH, KRTHB6, COL3A1, PDK3, NNAT, FLJ20510, FLJ20208, ANXA4, MMP7, ETS1, ABLIM, CPT1A, BARD1, OKL38, ATP1B1, TONDU, STC1, ABLIM, GCNT3, UCP3, SLC12A2, LOC51141, HSD17B2, ITIH2, INADL, ANXA4, RNASE6PL, CKS2, PABPC1, GJB1, CUTL1, SPTBN1, FLJ13881, LGALS4, C11ORF9, ARSE, LAMB3, MVP, UGT1A1, GLJ20053, CD74, BUB1B, CCND1, CCNE1, TOP2A, TYMS, ALDH1, and CYP3A5.
1 more element
A kit for characterizing cancer in a subject, comprising:
- a) a reagent capable of specifically detecting the level of expression of two or more drug sensitivity genes selected from the group consisting of ADAMTS2, MSH6, MAGEA6, RPS6KB1, PIK3CB, MDR3, MDR4, MDR9, OS4, KIAA1140, GCNT3, FARP1, PP1044, C11ORF15, KIAA0233, BZRP, PRPS1, HGFAC, TRPC4, LOC56889, FLJ20208, FLJ22833, PGLYRP, TNFRSF14, HLA-B, NPR3, DES, PCDH1, LLGL2, HMGCL, TSPAN, ANXA4, ABP1, ERP70, HSD17B2, FBP1, SIM1, LAF4, CRKL, TOB2, GDA, MMP7, PRSS8, CKS2, PGLYRP, KIF4A, PABPC1, FLJ21865, ETV4, EXTL3, PIK3C2A, DNMT3B, DKFZP566G1424, KIAA0026, CCNB1, GPC3, EVA1, FSTL3, MSLN, FLJ21935, DES, STK17A, KCNH2, DLK1, CPX, NRP1, PCTAIRE2BP, ELF3, AGR2, FLJ10849, ATP1B1, GPX2, SLI, AMPD1, OTC, MMP3, CPX, COX6A2, S100A4, LOC51315, MDS024, PCDH1, PGLYRP, NK4, TRAF2, ARHE, LOC51256, ITGA3, KIAA0971, KIAA1037, GABRA6, U1SNRNPBP, MYBL2, POLA2, TRH, KRTHB6, COL3A1, PDK3, NNAT, FLJ20510, FLJ20208, ANXA4, MMP7, ETS1, ABLIM, CPT1A, BARD1, OKL38, ATP1B1, TONDU, STC1, ABLIM, GCNT3, UCP3, SLC12A2, LOC51141, HSD17B2, ITIH2, INADL, ANXA4, RNASE6PL, CKS2, PABPC1, GJB1, CUTL1, SPTBN1, FLJ13881, LGALS4, C11ORF9, ARSE, LAMB3, MVP, UGT1A1, GLJ20053, CD74, BUB1B, CCND1, CCNE1, TOP2A, TYMS, ALDH1, and CYP3A5;
- and
- b) instructions for using said kit for characterizing cancer in said subject.
A method of screening compounds, comprising
- a) providing
- i) a cancer sample comprising a known drug sensitivity profile;
- wherein said drug sensitivity profile comprises a level of expression of two or more drug sensitivity genes selected from the group consisting of ADAMTS2, MSH6, MAGEA6, RPS6KB1, PIK3CB, MDR3, MDR4, MDR9, OS4, KIAA1140, GCNT3, FARP1, PP1044, C11ORF15, KIAA0233, BZRP, PRPS1, HGFAC, TRPC4, LOC56889, FLJ20208, FLJ22833, PGLYRP, TNFRSF14, HLA-B, NPR3, DES, PCDH1, LLGL2, HMGCL, TSPAN, ANXA4, ABP1, ERP70, HSD17B2, FBP1, SIM1, LAF4, CRKL, TOB2, GDA, MMP7, PRSS8, CKS2, PGLYRP, KIF4A, PABPC1, FLJ21865, ETV4, EXTL3, PIK3C2A, DNMT3B, DKFZP566G1424, KIAA0026, CCNB1, GPC3, EVA1, FSTL3, MSLN, FLJ21935, DES, STK17A, KCNH2, DLK1, CPX, NRP1, PCTAIRE2BP, ELF3, AGR2, FLJ10849, ATP1B1, GPX2, SLI, AMPD1, OTC, MMP3, CPX, COX6A2, S100A4, LOC51315, MDS024, PCDH1, PGLYRP, NK4, TRAF2, ARHE, LOC51256, ITGA3, KIAA0971, KIAA1037, GABRA6, U1SNRNPBP, MYBL2, POLA2, TRH, KRTHB6, COL3A1, PDK3, NNAT, FLJ20510, FLJ20208, ANXA4, MMP7, ETS1, ABLIM, CPT1A, BARD1, OKL38, ATP1B1, TONDU, STC1, ABLIM, GCNT3, UCP3, SLC12A2, LOC51141, HSD17B2, ITIH2, INADL, ANXA4, RNASE6PL, CKS2, PABPC1, GJB1, CUTL1, SPTBN1, FLJ13881, LGALS4, C11ORF9, ARSE, LAMB3, MVP, UGT1A1, GLJ20053, CD74, BUB1B, CCND1, CCNE1, TOP2A, TYMS, ALDH1, and CYP3A5;
- and
- ii) a plurality of test compounds;
- and
- b) determining the effectiveness of said test compound in treating said cancer.
4 more elements
Dependencies are inferred from the claim text.