Genes abnormally expressed in myeloid leukemia cells with an MLL-AF9 fusion

Abstract

The invention provides materials and methods for the analysis of gene expression in hematopoietic cells, such as hematopoietic stem/precursor cells of mammals. Materials of the invention include microarrays of polynucleotides collectively characterizing gene expression in hematopoietic cells, as well as a vector comprising at least one such polynucleotide and a host cell containing such a vector. Methods of the invention include diagnostic methods for identifying or detecting expression products collectively characteristic of normal, or abnormal, hematopoietic cells. Other methods of the invention include therapeutic methods for the treatment or prevention of an abnormality such as a disease or condition of a hematopoietic cell, comprising delivery of an effective amount of a suitable material, such as a pharmaceutical composition of the invention, to a cell or patient in need thereof.

Dependencies are inferred from the claim text.