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OwnerMaurice Cohen, Tracey L. Colpitts +5inventors
InventorsMaurice Cohen, Tracey L. Colpitts, Paula N. Friedman, Edward N. Granados, Michael R. Klass, John C. Russell, Stephen D. Stroupe
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A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS215 and transcribed from prostate tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate such as prostate cancer. Also provided are antibodies which specifically bind to PS215-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS215 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
A purified polynucleotide or fragment thereof derived from a PS215 gene, wherein said polynucleotide is capable of selectively hybridizing to the nucleic acid of said PS215 gene and has at least 50% identity to a sequence selected from the group consisting of SEQUENCE ID NO 1, SEQUENCE ID NO 2, SEQUENCE ID NO 3, SEQUENCE ID NO 4, SEQUENCE ID NO 5, SEQUENCE ID NO 6, SEQUENCE ID NO 7, and fragments or complements thereof.
A PS215 polypeptide having at least 50% identity with an amino acid sequence selected from the group consisting of SEQUENCE ID NO 10, SEQUENCE ID NO 11, and fragments thereof.
A method for detecting PS215 antigen in a test sample suspected of containing said PS215 antigen, comprising:
Dependencies are inferred from the claim text.