Human G-protein receptor HGBER32
AssigneeHuman Genome Sciences, Inc.
InventorsDaniel R. Soppet, Yi Li, Craig A. Rosen, Steven M. Ruben
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Abstract
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
Claims19
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide as set forth in FIGS. 1A-1D.
- (b) a polynucleotide encoding the polypeptide expressed by the DNA contained in ATCC Deposit No. 97187;
- (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b);
- and
- (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
A polypeptide selected from the group consisting of (i) a polypeptide having the deduced amino acid sequence of FIGS. 1A-1D and fragments, analogs and derivatives thereof;
- and (ii) a polypeptide encoded by the cDNA of ATCC Deposit No. 97187 and fragments, analogs and derivatives of said polypeptide.
Dependencies are inferred from the claim text.