Novel TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9 alpha2delta-4, 54414, and 53763 molecules and uses therefor

An isolated nucleic acid molecule selected from the group consisting of:

• (a) a nucleic acid molecule comprising a nucleotide sequence which is at least 60% identical to the nucleotide sequence of SEQ ID NO:1, 3, 4, 6, 14, 16, 21, 23, 28, 30, 31, 33, 34, 36, 37, 39, 40, 42, 43, 45, 52, 54, 55, 57, or a complement thereof;
• (b) a nucleic acid molecule comprising a fragment of at least 30 nucleotides of a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
• 1, 3, 4, 6, 14, 16, 21, 23, 28, 30, 31, 33, 34, 36, 37, 39, 40, 42, 43, 45, 52, 54, 55, 57, or a complement thereof;
• (c) a nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least about 60% identical to the amino acid sequence of SEQ ID NO:
• 2, 5, 15, 22, 29, 32, 35, 38, 41, 44, 53, or 56, or a complement thereof;
• and
• (d) a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
• 2, 5, 15, 22, 29, 32, 35, 38, 41, 44, 53, or 56, wherein the fragment comprises at least 10 contiguous amino acid residues of the amino acid sequence of SEQ ID NO:
• 2, 5, 15, 22, 29, 32, 35, 38, 41, 44, 53, or 56, or a complement thereof.

An isolated polypeptide selected from the group consisting of:

• a) a polypeptide comprising the amino acid sequence of SEQ ID NO:2, 5, 15, 22, 29, 32, 35, 38, 41, 44, 53, or 56;
• b) a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, 5, 15, 22, 29, 32, 35, 38, 41, 44, 53, or 56;
• c) a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
• 2, 5, 15, 22, 29, 32, 35, 38, 41, 44, 53, or 56, wherein the fragment comprises at least 10 contiguous amino acids of SEQ ID NO:
• 2, 5, 15, 22, 29, 32, 35, 38, 41, 44, 53, or 56;
• d) a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:
• 2, 5, 15, 22, 29, 32, 35, 38, 41, 44, 53, or 56, wherein the polypeptide is encoded by a nucleic acid molecule which hybridizes to complement of a nucleic acid molecule consisting of SEQ ID NO:
• 1, 3, 4, 6, 14, 16, 21, 23, 28, 30, 31, 33, 34, 36, 37, 39, 40, 42, 43, 45, 52, 54, 55, 57 under stringent conditions;
• e) a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 60% identical to a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
• 1, 3, 4, 6, 14, 16, 21, 23, 28, 30, 31, 33, 34, 36, 37, 39, 40, 42, 43, 45, 52, 54, 55, 57;
• and
• f) a polypeptide comprising an amino acid sequence which is at least 60% identical to the amino acid sequence of SEQ ID NO:
• 2, 5, 15, 22, 29, 32, 35, 38, 41, 44, 53, or 56.