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AssigneeAkzo Nobel N.V.
InventorsTheodorus Petrus Maria Schetters, Bernard Pierre Dominique Carcy, Pascal Robert Drakulovski
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The present invention relates to nucleic acid sequences encoding novel Babesia canis associated proteins and to cDNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Furthermore, the invention relates to host cells comprising such nucleic acid sequences, cDNA fragments, recombinant DNA molecules and live recombinant carriers. Also, the invention relates to proteins encoded by these nucleotide sequences, to vaccines for combating Babesia canis infections comprising these proteins or genetic material encoding these proteins and methods for the preparation of vaccines. Another embodiment of the invention relates to these Babesia canis associated proteins for use in vaccines and to the use of the Babesia canis associated proteins in the manufacture of vaccines. Finally the invention relates to diagnostic tools for the detection of Babesia canis associated nucleic acid sequences, for the detection of Babesia canis associated antigens and for the detection of antibodies against Babesia canis associated antigenic material.
1) Nucleic acid sequence encoding a 15 kD Babesia canis associated protein or an immunogenic fragment of said protein, said protein or immunogenic fragment thereof having at least 80%, preferably 90%, more preferably 95% homology with the amino acid sequence as depicted in SEQ ID NO:
2) Nucleic acid sequence encoding a 32 kD Babesia canis associated protein or an immunogenic fragment of said protein, said protein or immunogenic fragment thereof having at least 80%, preferably 90%, more preferably 95% homology with the amino acid sequence as depicted in SEQ ID NO:
7) Babesia canis associated protein, said protein having a molecular weight of 15 kD and comprising an amino acid sequence that is at least 80% homologous to the amino acid sequence as depicted in SEQ ID NO:
9) Babesia canis associated protein, said protein having a molecular weight of 32 kD and comprising an amino acid sequence that is at least 80% homologous to the amino acid sequence as depicted in SEQ ID NO:
20) Diagnostic test for the detection of Babesia canis associated RNA characterised in that the test comprises a nucleic acid sequence that is at least 70% homologous to the nucleic acid sequence as depicted in SEQ ID NO:
Dependencies are inferred from the claim text.