Marker genes responding to treatment with toxins
OwnerMary Jane Cunningham, Matthew R. Kaserinventors
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Abstract
The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed in treated rat liver and in human liver and which may be used in their entirety or in part to diagnose, stage, or treat a liver disorder, to monitor diagnostic and therapeutic applications, to detect metabolic and toxicological responses, and to elucidate drug mechanism of action.
Claims20
A combination comprising a plurality of cDNAs that are differentially expressed in a liver treated with a toxin and are selected from SEQ ID NOs:
- 1-514 and the complements thereof.
A combination comprising a plurality of cDNAs that are differentially expressed in a liver disorder and are selected from:
- a) SEQ ID NOs:
- 1-202;
- b) SEQ ID NOs:
- 203-399;
- c) SEQ ID NOs:
- 400-514;
- and
- d) the complement of (a), (b), or (c).
An isolated cDNA selected from SEQ ID NOs:
- 411, 441, 432, 450, 457, 465, 474, 477, 499, 501, 510.
Dependencies are inferred from the claim text.