US 2003/0165851 A1Published application

Novel polypetides and nucleic acids encoding same

OwnerShlomit R. Edinger, John R. MacDougal +25inventors

InventorsShlomit R. Edinger, John R. MacDougal, Isabelle Millet, Karen Ellerman, David J. Stone, Valerie Gerlach, William M. Grosse, John P. Alsobrook II, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess, Stacie J. Casman, Kimberly A. Spytek, Ference L. Boldog, Li Li, Muralidhara Padigaru, Vishnu Mishra, Meera Patturajan, Suresh G. Shenoy, Luca Rastelli, Velizar T. Tchernev, Corine A.M. Vernet, Bryan D. Zerhusen, Uriel M. Malyankar, Xiaojia (Sasha) Guo, Charles E. Miller, Esha A. Gangolli

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Abstract

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Claims49

Dependent claims

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:
2, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, or 56;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:
2, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, or 56, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting SEQ ID NO:
2, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, or 56;
and
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NO:
2, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, or 56, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence.

6 more elements

An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:
2, 22, 24, 26, 28, 30, 32, 34,36, 38, 40, 42, 44, 46, 48, 50, 52, 54, or 56;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:
2, 22, 24, 26, 28, 30, 32,34, 36, 38,40, 42, 44, 46, 48, 50, 52, 54, or 56, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NO:
2, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, or 56;
(d) a variant of an amino acid sequence selected from the group consisting SEQ ID NO:
2, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, or 56, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
(e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising an amino acid sequence chosen from the group consisting of SEQ ID NO:
2, 22, 24, 26, 28,30, 32, 34, 36, 38,40, 42,44,46, 48, 50, 52, 54, or 56, or a variant of said polypeptide, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
and
(f) a nucleic acid molecule comprising the complement of (a), (b), (c), (d) or (e).

9 more elements

Dependencies are inferred from the claim text.