Loading patent…
OwnerAvi Shoshan, Alon Wasserman +3inventors
InventorsAvi Shoshan, Alon Wasserman, Eli Mintz, Liat Mintz, Simchon Faigler
Estimating the term…
The present invention provides oligonucleotide libraries capable of detecting RNA transcripts and RNA splice variants which populate a transcriptome and which are transcribed from genes or transcription units that populate the corresponding genome. The present invention also provides oligonucleotide arrays generated from the oligonucleotide libraries and methods of using the oligonucleotide libraries in various oligonucleotide detection systems and expression profiling studies. Antisense molecules and double-stranded interfering RNAs, which are types of oligonucleotides, based on the oligonucleotides disclosed herein also are provided.
An oligonucleotide library for detecting messenger RNAs that populate a transcriptome, wherein the transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a genome, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to a set of messenger RNAs transcribed from a given transcription unit of the genome, wherein at least one transcription unit of the genome encodes one or more messenger RNA splice variants.
An oligonucleotide library for detecting messenger RNAs that populate a sub transcriptome of a tissue origin, wherein the sub transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a sub genome of the tissue origin, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to a set of messenger RNAs transcribed from a given transcription unit of the sub genome, wherein at least one transcription unit of the sub genome encodes one or more messenger RNA splice variants.
An oligonucleotide library for detecting messenger RNAs that populate a sub transcriptome of a pathological tissue origin, wherein the sub transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a sub genome of the pathological tissue origin, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to a set of messenger RNAs transcribed from a given transcription unit of the sub genome, wherein at least one transcription unit of the sub genome encodes one or more messenger RNA splice variants.
An oligonucleotide library for detecting messenger RNAs that populate a sub transcriptome of a developmental stage, wherein the sub transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a sub genome of the developmental stage, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to a set of messenger RNAs transcribed from a given transcription unit of the sub genome, wherein at least one transcription unit of the sub genome encodes one or more messenger RNA splice variants.
An oligonucleotide library for detecting messenger RNAs that populate a transcriptome of patients suffering from a disorder, wherein the transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a genome of patients suffering from the disorder, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to a set of messenger RNAs transcribed from a given transcription unit of the genome, wherein at least one transcription unit of the genome encodes one or more messenger RNA splice variants.
An oligonucleotide library for detecting messenger RNAs that populate a transcriptome, wherein the transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a genome, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to one or a subset of messenger RNAs transcribed from a given transcription unit of the genome, wherein at least one transcription unit of the genome encodes one or more messenger RNA splice variants.
An oligonucleotide library for detecting messenger RNAs that populate a sub transcriptome of a tissue origin, wherein the sub transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a sub genome of the tissue origin, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to one or a subset of messenger RNAs transcribed from a given transcription unit of the sub genome, wherein at least one transcription unit of the sub genome encodes one or more messenger RNA splice variants.
An oligonucleotide library for detecting messenger RNAs that populate a sub transcriptome of a pathological tissue origin, wherein the sub transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a sub genome of the pathological tissue origin, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to one or a subset of messenger RNAs transcribed from a given transcription unit of the sub genome, wherein at least one transcription unit of the sub genome encodes one or more messenger RNA splice variants.
An oligonucleotide library for detecting messenger RNAs that populate a sub transcriptome of a developmental stage, wherein the sub transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a sub genome of the developmental stage, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to one or a subset of messenger RNAs transcribed from a given transcription unit of the sub genome, wherein at least one transcription unit of the sub genome encodes one or more messenger RNA splice variants.
An oligonucleotide library for detecting messenger RNAs that populate a transcriptome of patients suffering from a disorder, wherein the transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a genome of patients suffering from the disorder, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to one or a subset of messenger RNAs transcribed from a given transcription unit of the genome, wherein at least one transcription unit of the genome encodes one or more messenger RNA splice variants.
A double stranded RNA molecule based on an oligonucleotide selected from an oligonucleotide library for detecting messenger RNAs that populate a transcriptome, wherein the transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a genome, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to a set of messenger RNAs transcribed from a given transcription unit of the genome, wherein at least one transcription unit of the genome encodes one or more messenger RNA splice variants, wherein
An antisense molecule based on an oligonucleotide selected from an oligonucleotide library for detecting messenger RNAs that populate a transcriptome, wherein the transcriptome comprises messenger RNAs transcribed from a multiplicity of transcription units that populate a genome, wherein the library comprises a plurality of oligonucleotides, wherein each oligonucleotide in the plurality is capable of hybridizing selectively to a set of messenger RNAs transcribed from a given transcription unit of the genome, wherein at least one transcription unit of the genome encodes one or more messenger RNA splice variants, wherein
Dependencies are inferred from the claim text.