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OwnerNicholas J. Schork, Laurent Essioux +3inventors
InventorsNicholas J. Schork, Laurent Essioux, Annick Cohen-Akenine, Marta Blumenfeld, Daniel Cohen
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The present invention relates to methods, software, and apparati for determining whether a genomic region harbors a gene associated with a detectable trait. In one embodiment, the present invention relates to a method of confirming that a genomic region harbors a gene associated with a detectable trait comprising the steps of identifying a candidate genomic region suspected of harboring the gene associated with the detectable trait, constructing a trait-associated distribution of association values using the biallelic markers in the candidate genomic region, identifying a plurality of biallelic markers in random genomic regions which are not suspected of harboring the gene associated with the detectable trait, constructing a random distribution of association values using the biallelic markers in the random genomic regions, comparing the trait-associated distribution of association values to the random distribution of association values, and determining whether the trait-associated distribution of association values and the random distribution of association values are significantly different from one another. In other embodiments, the present invention comprises software for performing the above method and devices comprising the software in a retrievable form.
A method of confirming that a candidate genomic region harbors a gene associated with a detectable trait comprising the steps of:
A method of determining whether a candidate genomic region harbors a gene associated with a detectable trait comprising determining whether the association of a plurality of biallelic markers located in said candidate genomic region with said detectable trait is significantly different than the association of a plurality of biallelic markers located in a plurality of random genomic regions.
A computer system for confirming that a candidate genomic region harbors a gene associated with a detectable trait, wherein the computer system comprises instructions that when executed perform the method of:
A programmed storage device comprising instructions that when executed perform the steps of:
Dependencies are inferred from the claim text.