PG-3 and biallelic markers thereof
OwnerCaroline Barry, Ilya Chumakovinventors
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Abstract
The invention concerns the genomic sequence and cDNA sequences of the PG-3 gene. The invention also concerns biallelic markers of the PG-3 gene. The invention also concerns polypeptides encoded by the PG-3 gene. The invention also deals with antibodies directed specifically against such polypeptides that are useful as diagnostic reagents.
Claims13
A composition comprising an isolated, purified or recombinant nucleic acid molecule comprising a polynucleotide sequence selected from the group consisting of:
- a) a contiguous span of at least 200 nucleotides of SEQ ID No 1 or the complement thereof, wherein said contiguous span comprises at least one of the following nucleotide positions of SEQ ID No 1:
- 1-97921, 98517-103471, 103603-108222, 108390-109221, 109324-114409, 114538-115723, 115957-122102, 122225-126876, 127033-157212, 157808-240825;
- b) a contiguous span of at least 15 nucleotides of SEQ ID No 2 or the complement thereof;
- c) a contiguous span of at least 15 nucleotides of anyone of SEQ ID Nos 1 and 2 or the complements thereof, wherein said span includes a PG-3-related biallelic marker selected from the group consisting of A1 to A5 and A8 to A80, and the complements thereof;
- d) a polynucleotide consisting essentially of a sequence selected from the following sequences:
- P1 to P4 and P6 to P80, and the complementary sequences thereto;
- e) a polynucleotide consisting essentially of a sequence selected from the following sequences:
- D1 to D4, D6 to D80, E1 to E4, and E6 to E80;
- f) a polynucleotide consisting essentially of a sequence selected from the following sequences:
- B1 to B52 and C1 to C52;
- and
- g) a polynucleotide which encodes a polypeptide comprising a contiguous span of at least 6 amino acids of SEQ ID No 3.
A composition comprising an isolated, purified, or recombinant polypeptide comprising a 2 contiguous span of at least 6 amino acids of SEQ ID No 3.
A method of genotyping comprising determining the identity of a nucleotide at a PG-3-related biallelic marker or the complement thereof in a biological sample.
Dependencies are inferred from the claim text.