Novel protein
OwnerMark Robert Edbrooke, Alan Peter Lewisinventors
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Abstract
The present invention provides a method for identification of a substance that modulates serine protease activity, which method comprises: (i) contacting (a) a cell selected from a neuronal cell, a lung cell, an intestinal cell and a cell infected with a virus, which cell expresses a serine protease polypeptide comprising the amino acid sequence of SEQ ID NO: 2 or a variant thereof which has dipeptidyl peptidase activity with (b) a test substance; and (ii) monitoring for serine protease activity.
Claims17
A method for identification of a substance that modulates serine protease activity, which method comprises:
- (i) contacting
- (a) a cell selected from a neuronal cell, a lung cell, an intestinal cell and a cell infected with a virus, which cell expresses a serine protease polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2 or a variant thereof which has dipeptidyl peptidase activity with
- (b) a test substance;
- and
- (ii) monitoring for serine protease activity.
A method for identification of a substance that modulates serine protease activity, which method comprises:
- (i) contacting
- (a) a serine protease polypeptide isolated from a cell selected from a neuronal cell, a lung cell, an intestinal cell and cell infected with a virus, which serine protease comprises the amino acid sequence of SEQ ID NO:
- 2 or a variant thereof which has dipeptidyl peptidase activity;
- with
- (b) a test agent;
- and
- (ii) monitoring for serine protease activity.
A method of treating a subject suffering from a disease selected from a musculoskeletal disease, a HBV disease, Alzheimer's disease, parasupranuclear palsy, myotonic dystrophy, Huntington's disease and amyotrophic lateral sclerosis, which method comprises administering to said subject an effective amount of a substance which modulates proteinase activity of a polypeptide with the amino acid sequence shown in SEQ ID NO:
- 2 or a variant thereof.
A method for treating a disease selected from a musculoskeletal disease, a HBV disease, Alzheimer's disease, parasupranuclear palsy, myotonic dystrophy, Huntington's disease and amyotrophic lateral sclerosis, which method comprises:
- (i) identifying a substance that modulates serine protease activity and/or expression
- (ii) administering an effective amount of the substance to a patient suffering from a disease selected from a musculoskeletal disease, a HBV disease, Alzheimer's disease, parasupranuclear palsy, myotonic dystrophy, Huntington's disease and amyotrophic lateral sclerosis.
Dependencies are inferred from the claim text.