Compaction assay for assessment of respiratory disease therapy
AssigneeGenentech, Inc.
InventorsAnn L. Daugherty, Randy J. Mrsny, Thomas W. Patapoff
Life of this patent
Estimating the term…
Abstract
A compaction assay measuring the viscoelasticity of sputum samples of patients subject to respiratory disease is provided. This assay is useful in determining the therapeutic efficacy of DNase, antibiotic and other respiratory disease treatments in improving lung function.
Claims22
A method for measuring the compaction of a sputum sample from a mammalian patient subject to respiratory disease associated with infected airway secretions, comprising obtaining a sputum sample from the mammalian patient, centrifuging said sputum sample until fractionated into supernatant and pellet phases, and measuring the pellet.
A method for measuring the compaction of a mammalian patient sputum sample treated in vitro with a therapeutic, comprising obtaining a sputum sample from the mammalian patient, adding therapeutic to the sputum sample, centrifuging said sputum sample until fractionated into supernatant and pellet phases, and measuring the pellet.
A method of assaying the compaction of a DNase treated sputum sample from a mammalian patient in need of DNase therapy comprising, obtaining a sputum sample from the mammalian patient, adding DNase to the sputum sample, centrifuging the DNase treated sputum until fractionated into supernatant and pellet phases, and measuring the pellet.
Dependencies are inferred from the claim text.