Methods, apparatus and computer program products for formulating culture media

A method of identifying a culture medium component, comprising the steps of:

• defining a first test library by representing each of a plurality of groups of compound isomers from within a compound space as a respective candidate compound;
• measuring first indicia of a property of a plurality of first culture media which each contains a respective first test compound from within the first test library;
• determining a relationship between at least one parameter of the first test compounds and the measured first indicia of the property of the plurality of first culture media;
• determining a test requirement relating to the measured first indicia;
• and
• identifying a plurality of second test compounds from within the compound space as components of a plurality of second culture media which based on the relationship are expected to provide second indicia of the property which meets the test requirement.

A method of identifying a peptide with a predicted indicia of an activity that satisfies a test requirement, comprising the steps of:

• measuring first indicia of an activity of a plurality of first test peptides from a first test peptide library;
• determining a relationship between the measured first indicia of the activity and at least one whole molecule parameter of the plurality of first test peptides;
• determining a test requirement relating to the measured first indicia;
• and
• identifying a second test peptide library containing a plurality of second test peptides which based on the relationship are expected to provide second indicia of the activity that meets the test requirement.

A method of identifying a culture medium component, comprising the steps of:

• culturing a plurality of first cell cultures in a plurality of first culture media each containing a respective first test compound from a first test library;
• measuring first indicia of a property of the plurality of first culture media in the plurality of first cell cultures;
• determining a relationship between the measured first indicia of the property and at least one parameter of the plurality of first culture media;
• determining a test requirement relating to the measured first indicia;
• and
• culturing a plurality of second cell cultures in a plurality of second culture media each containing a respective second test compound from a second test library;
• wherein based on the relationship the plurality of second culture media containing the second test compounds are predicted to give indicia of the property that satisfy the test requirement.