US 2003/0165588 A1 · Identification of free-B-ring flavonoids as potent COX-2 inhibitors

Abstract

The present invention provides a novel method for inhibiting the cyclooxygenase COX-2. The method is comprised of administering a composition containing a Free-enzyme B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.

Claims18

Dependent claims

A method for inhibiting the cyclooxygenase enzyme COX-2 comprising administering a composition comprising a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids.

Dependencies are inferred from the claim text.

Facts

Application

10/091,362Filed 1 Mar 2002

Published

4 Sep 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 31/7048
Compounds having saccharide radicals and heterocyclic rings: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin,…
A61K 31/353
Condensed with carbocyclic rings, e.g. methantheline: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61P 15/08
Drugs for genital or sexual disorders ; Contraceptives: for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of…
A61P 17/00
Drugs for dermatological disorders

Identification of free-B-ring flavonoids as potent COX-2 inhibitors

Life of this patent

Identification of free-B-ring flavonoids as potent COX-2 inhibitors

Life of this patent

Abstract

Claims18