Compositions for treating diabetes mellitus, methods of use and manufacturing process of the same
OwnerPeng Wang, Lin Leiinventors
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Abstract
The present invention provides novel compositions and methods for lowering blood glucose levels, as well as manufacture processes for producing the compositions. Specifically, the present invention provides novel compositions that are extracts of the plant Prunella Linn and/or Rabdosis (Blume) Hasskarl containing enriched corosolic acid. Methods of isolating corosolic acid at high purity from these plants are also provided. These extracts and the purified corosolic acid can be used for lowering blood sugar levels and reducing accumulation of triglyeride in the treatment of diabetes, obesity and related conditions.
Claims64
A composition comprising:
- extract of a plant Prunella Linn or Rabdosis (Blume) Hasskarl containing corosolic acid at a concentration of at least 0.01% by weight.
A pharmaceutically acceptable composition, comprising:
- a pharmaceutically acceptable excipient;
- and
- extract of a plant Prunella Linn or Rabdosis (Blume) Hasskarl containing corosolic acid at a concentration of at least 0.01% by weight.
A method for lowering blood sugar levels of a mammal, comprising:
- administering to the mammal a hypoglycemically effective amount of an extract of a plant Prunella Linn or Rabdosis (Blume) Hasskarl containing corosolic acid at a concentration of at least 0.01% by weight.
The method of 20, wherein the extract administered to the mammal via inhalation.
The method for manufacturing an extract of a plant Prunella Linn or Rabdosis (Blume) Hasskarl containing corosolic acid, comprising:
- extracting a plant material from Prunella Linn or Rabdosis (Blume) Hasskarl in a first polar solvent such that the resulting extract contains corosolic acid at a concentration of at least 0.01%.
Dependencies are inferred from the claim text.