Stabilized steroidal suspension
OwnerGiuseppe Colombo, Alessandro Martini +1inventors
InventorsGiuseppe Colombo, Alessandro Martini, Sharron Buttler
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Abstract
A pharmaceutical aqueous suspension formulation for parenteral administration having substantially stabilized pH, comprising a biologically active compound and a pH controlling effective concentration of a polyvinylpyrrolidone compound. Preferably the biologically active compound is a steroidal compound, for instance, exemestane, medroxyprogesterone acetate or estradiol cypionate or a combination of medroxyprogesterone acetate and estradiol cypionate.
Claims13
A pharmaceutical aqueous suspension formulation for parenteral administration having substantially stabilized pH, comprising a biologically active compound and a pH controlling effective concentration of a polyvinylpyrrolidone compound.
A pharmaceutical aqueous suspension formulation for parenteral administration having substantially stabilized pH, comprising a biologically active compound, a buffering agent and a polyvinylpyrrolidone compound in concentrations effective to produce a pH controlling superadditive effect.
A pharmaceutical composition, according to any preceding claims, wherein the pH range of formulation is from about pH 3.0 to about pH 8.0.
Use of a polyvinylpyrrolidone compound, in the preparation of a pharmaceutical aqueous suspension formulation having substantially stabilized pH, for parenteral administration of a biologically active compound, characterized in that a pH controlling effective concentration of polyvinylpyrrolidone is added thereto.
Use of a polyvinylpyrrolidone compound and a buffering agent in concentrations effective to produce a pH controlling superadditive effect, in the preparation of a pharmaceutical aqueous suspension formulation having substantially stabilized pH, for parenteral administration of a biologically active compound.
Dependencies are inferred from the claim text.