Histidine copolymer and methods for using same
OwnerA. James Mixsoninventor
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Abstract
The invention provides a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport polymer comprising one or more backbones, one or more terminal branches, and optionally, one or more non-terminal branches. The branched transport polymer may be associated with a pharmaceutical agent to form a pharmaceutical agent delivery composition useful for in vivo therapies based on local injection.
Claims20
A branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport polymer comprising one or more backbones, one or more terminal branches, and optionally, one or more non-terminal branches.
A pharmaceutical agent delivery composition for in vivo therapies based on local injection, said pharmaceutical agent delivery composition comprising a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport polymer comprising one or more backbones, one or more terminal branches, and optionally, one or more non-terminal branches;
- and a pharmaceutical agent associated with said branched transport polymer.
A method of in vivo therapy based on local injection comprising the steps of:
- preparing a pharmaceutical agent delivery composition comprising a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport polymer comprising one or more backbones, one or more terminal branches, and optionally, one or more non-terminal branches;
- and a therapeutic agent associated with said transport polymer;
- and
- administering the pharmaceutical agent delivery composition by local injection to a patient in need thereof.
Dependencies are inferred from the claim text.