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US 2003/0165565 A1Published application
Chrono delivery formulations and method of use thereof
AssigneeElite Laboratories, Inc.
InventorAtul M. Mehta
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AssigneeElite Laboratories, Inc.
InventorAtul M. Mehta
Estimating the term…
A dosage formulation for once daily administration prior to sleeping is described that provides an initial delay in pharmaceutical release followed by controlled release of the pharmaceutical. There is also provided a method for preparing a time specific delayed, controlled release formulation of dosage, which method includes coating a single pellet with at least one dosage layer, which is coated by at least one seal coat and at least one outer rate controlling layer of a water soluble polymer coat. The dosage formulation of this invention provides substantially a drug free interval of about 0 to 5 hours followed by a drug delivery interval at a rate permitting bioavailability thereof for up to about 24 hours following oral administration. A method of using the formulations of the present invention for the treatment of early morning pathologies is also described.
A time specific delayed release dosage formulation for administration once daily prior to sleep which comprises a biologically inert pellet comprising:
A method of preventing, treating or controlling hypertension or angina, in a subject in need thereof, comprising orally administering to said subject once prior to sleep a dosage formulation comprising a biologically inert pellet comprising a drug layer comprising a dosage form of a pharmaceutical agent and a binder agent, said binder agent and said pharmaceutical agent being present in a ratio of about 0.5:20;
Dependencies are inferred from the claim text.