Antimicrobial material for implanting in bones
AssigneeBio-Gate Bioinnovative Materials GmbH
InventorsThorsten Bechert, Peter Steinrucke
Life of this patent
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Abstract
The invention relates to an antimicrobial material for implanting in bones and for coating or producing an implant or an implantable medical device, whereby particles formed from an antimicrobial material are remotely dispersed inside a matrix material that forms a matrix when hardened. In order to improve the compatibility of the antimicrobial material, the invention provides that the metal is formed from aggregates of primary particles having an average particle size ranging from 10 to 100 nm.
Claims27
An antimicrobial material for implanting in bones, for coating or producing an implant or an implantable medical device, where particles formed from an antimicrobial metal are finely dispersed in a matrix material which forms a matrix in the cured state, characterized in that the metal is formed from aggregates of primary particles with an average particle size between 10 and 100 nm.
The antimicrobial material as claimed in any of the preceding claims, where the aggregates have a porosity of up to 95%.
The antimicrobial material as claimed in any of the preceding claims, where the aggregates are produced by inert gas vaporization and condensation, preferably under a pressure of from 10 to 100 mbar of inert gas.
The antimicrobial material as claimed in any of the preceding claims, where the metal is formed from one or more of the following components:
- Ag, Au, Pt, Pd, Ir, Sn, Cu, Sb, Zn.
The antimicrobial material as claimed in any of the preceding claims, where the metal has an essentially undisordered lattice structure.
The antimicrobial material as claimed in any of the preceding claims, where the metal content is not more than 2.0% by weight, preferably 0.01 to 2.0% by weight, based on the weight of the matrix material.
The antimicrobial material as claimed in any of the preceding claims, where the polymer comprises acylic esters and/or metacrylic esters.
The antimicrobial material as claimed in any of the preceding claims, where the aggregates are completely infiltrated with the matrix material.
The antimicrobial material as claimed in any of the preceding claims, where the matrix material is a polymer preferably formed from a plurality of components.
The antimicrobial material as claimed in any of the preceding claims, where the aggregates are homogeneously dispersed in the implant material.
An implant or implantable medical device formed from or at least partially coated with the antimicrobial material as claimed in any of the preceding claims.
A process for producing the material as claimed in any of the preceding claims having the following steps:
- a) vaporization and condensation of metal under inert gas atmosphere, where the pressure of the inert gas and the vaporization temperature are adjusted so that aggregates consisting of primary particles having an average particle size of from 10 to 100 nm are formed, and
- b) mixing of the aggregates with a curable matrix material.
Dependencies are inferred from the claim text.