Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same
AssigneeAllergan, Inc.
InventorsStanley W. Huth, Orest Olejnik, Zhi-Jian Yu
Life of this patent
Estimating the term…
Abstract
Ophthalmic compositions comprising an oil-in-water emulsion, preferably a self-emulsifying oil-in-water emulsion, including an oily component, an aqueous component and a surfactant component. The surfactant component may include three or more surfactants, for example, a polyoxyalkalene alkylene ether, a polyalkylene oxide ether of alkyl alcohol and a polyalkylene oxide ether of alkylphenol. The present compositions may include therapeutic components. Methods of making such compositions and using such compositions, for example, to treat eyes, to treat contact lenses and to provide desired therapeutic effects are provided.
Claims70
An ophthalmic composition comprising an oil-in-water emulsion including an oily component, an aqueous component, and a surfactant component including a first surfactant, a second surfactant and a third surfactant, wherein each of the surfactants is different from the other surfactant.
An ophthalmic composition comprising an oil-in-water emulsion including an oily component, an aqueous component, and a surfactant component including a first surfactant, a second surfactant and a third surfactant, each surfactant includes a hydrophobic constituent and a hydrophilic constituent, the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in chemical structure, and the hydrophilic constituent of the second surfactant and the hydrophilic constituent of the third surfactant are substantially similar in chemical structure.
An ophthalmic composition comprising a therapeutic component and an oil-in-water emulsion including an oily component, an aqueous component and a surfactant component including a first surfactant, a second surfactant and a third surfactant, wherein each of the surfactants is different from the other surfactants.
An ophthalmic composition comprising a therapeutic component, and an oil-in-water emulsion including an oily component, an aqueous component and a surfactant component including a first surfactant, a second surfactant and a third surfactant, each surfactant includes a hydrophobic constituent and a hydrophilic constituent, the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in chemical structure, and the hydrophilic constituent of the second surfactant and the hydrophilic constituent of the third surfactant are substantially similar in chemical structure.
A method of preparing an ophthalmic composition comprising:
- providing an oily component to a temperature above a melting temperature of the oily component;
- combining a surfactant component with the oily component to form an admixture, wherein the surfactant component includes a first surfactant, a second surfactant and a third surfactant, and each of the surfactants is different from the other surfactants;
- and
- combining the admixture with an aqueous phase to form an oil-in-water emulsion.
A method comprising contacting a contact lens with a composition comprising an oil-in-water emulsion, the contacting being effective in providing the contact lens with at least one benefit selected from the group consisting of lubricating the contact lens, preventing dehydration of the contact lens and preventing protein deposition on the contact lens.
Dependencies are inferred from the claim text.