Methods and compositions for promoting immunopotentiation
AssigneeArch Development Corporation
InventorJeffery A. Bluestone
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Abstract
This invention discloses immunopotentiating agents which stimulate an immune resposne. These agents are categorized into single agents that act directly, adjuvants added concurrently with the agents, or heteroconjugates. Heteroconjugate agents eleicit or enhance a cellular or humoral immune response which may be specific for an epitope contained within an amino acid sequence. Enhanced hematopoieses by bone marrow stem cell recruitment was also a result of administering some of these agents.
Claims54
An immunopotentiating composition comprising:
- (a) an immunopotentiating protein;
- and
- (b) a second compound having an epitope against which a cellular or humoral immune response is desired.
A method of preparing a heteroconjugate agent for eliciting or enhancing a cellular or humoral immune response to an epitope contained within an amino acid sequence, the method comprising the steps of:
- (a) obtaining an immunopotentiating protein;
- and
- (b) conjugating to said immunopotentiating protein a second compound to form the heteroconjugate agent, the second compound having an epitope against which a cellular or humoral immune response is desired.
A method of stimulating or enhancing the immune system of a mammal which comprises preparing an immunopotentiating composition which includes an immunopotentiating agent characterized as having an ability to stimulate an immune response;
- combining the agent in a pharmaceutically acceptable vehicle;
- administering the resulting compound to the mammal in amounts effective to stimulate an immune response.
A method for recruiting hematopoietic bone marrow stem cells of an organism, said method comprising administering an immunopotentiating agent in an amount effective to stimulate the development of said stem cells.
A method for enhancing the engraftment of hematopoietic tissue transplants in an individual receiving such a transplant, said method comprising administering to said individual an amount of an immunopotentiating agent effective to stimulate stem cell recruitment.
A method of preparing immunological products, comprising the steps of:
- (a) immunizing mammals with an immunopotentiating composition which includes an immunopotentiating agent;
- and
- (b) obtaining immunological products from said immunized mammal, said products including T cells, B cells or antibodies.
Dependencies are inferred from the claim text.